Guidelines for Using the Exelon Patch

Review these tips for applying or wearing the Exelon Patch:

  • Use Exelon Patch exactly as instructed by your loved one's healthcare provider.
  • Exelon Patches come in 3 different dosage strengths.
  • Your loved one's healthcare provider may change the dose as needed.
  • Only 1 Exelon Patch should be worn at a time.
  • Exelon Patch is for skin use only
  • Only apply Exelon Patch to healthy skin that is clean, dry, hairless, and free of redness, irritation, burns or cuts.
  • Avoid applying Exelon Patch to areas on your loved one's body that will be rubbed against tight clothing.
  • Do not apply Exelon Patch to skin that has cream, lotion, or powder on it.
  • Change your loved one's Exelon Patch every 24 hours at the same time of day. You may write the date and time on the Exelon Patch with a ballpoint pen before applying the patch to help you remember when to remove it.
  • Change the application site every day to avoid skin irritation. You can use the same area, but do not use the exact same spot for at least 14 days after the last application.
  • Check to see if the Exelon Patch has become loose when your loved one is bathing, swimming, or showering.
  • Exelon Patch is designed to deliver medication during the time it is worn. If your loved one's Exelon Patch falls off before its usual replacement time, put on a new Exelon Patch right away. Replace the new patch the next day at the same time as usual. Do not use overlays, bandages, or tape to secure an Exelon Patch that has become loose or try to reapply an Exelon Patch that has fallen off.
  • If your loved one misses a dose or you forget to change their Exelon Patch apply their next Exelon Patch as soon as you remember. Do not apply 2 Exelon Patches to make up for the missed dose.
  • If your loved one misses more than 3 doses of applying Exelon Patch, call the healthcare provider before putting on a new Exelon Patch. Your loved one may need to re-start Exelon Patch at a lower dose.
  • Always remove the old Exelon Patch from the previous day before a new one is applied.

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Each patch is sealed in its own protective pouch. You should only open the pouch when you are ready to apply the Exelon Patch.

Before applying the patch, make sure the skin is:

  • Clean and hairless
  • Free of any powder, oil, moisturizer, or lotion (that could keep the patch from sticking to your skin properly)
  • Free of cuts, rashes, or irritations

Only one Exelon Patch should be worn at a time.

For step by step instructions click here:

Indications & Important Safety Information


EXELON® PATCH (rivastigmine transdermal system) is a prescription medicine used to treat mild, moderate, and severe memory problems (dementia) associated with Alzheimer's disease.

EXELON PATCH is also used to treat people with mild to moderate memory problems (dementia) associated with Parkinson's disease.


EXELON PATCH should not be used if the patient is allergic to any component in EXELON PATCH, including the active ingredient rivastigmine. EXELON PATCH should also not be used if the patient has had a skin reaction that spread beyond the patch size, had blisters, increased skin redness, or swelling, or did not get better within 48 hours after removal of the EXELON PATCH.

Mistakes in using EXELON PATCH have resulted in serious side effects; some cases have required hospitalization, and rarely, have led to death. Most mistakes have involved not removing the old patch when putting on a new one and the use of multiple patches at one time. Only one EXELON PATCH should be worn at a time. If you accidentally apply more than one EXELON PATCH, remove all of them and inform the doctor immediately.

EXELON PATCH can also cause serious stomach side effects, including nausea, vomiting, diarrhea, dehydration, decreased appetite, weight loss, and bleeding in your stomach (ulcers). Dehydration may result from prolonged vomiting or diarrhea and can be associated with serious outcomes. Some people have had a serious skin reaction called allergic contact dermatitis (ACD) when using EXELON PATCH. Stop using EXELON PATCH and call your health care provider right away if you experience reactions that spread beyond the patch size, are intense in nature, and do not improve within 48 hours after the patch is removed. Symptoms of ACD may be intense and include itching, redness, swelling, warmth or tenderness of the skin, or peeling or blistering of the skin, which may ooze, drain, or crust over. The incidence and severity of these reactions are dose related. For this reason, treatment should be initiated with EXELON PATCH at a dose of 4.6 mg/24 hours and titrated to a dose of 9.5 mg/24 hours, and then 13.3 mg/24 hours, if appropriate. If you have not taken EXELON PATCH for more than 3 days, do not start taking it again until you have talked with a doctor.

The most common side effects of EXELON PATCH include depression, headache, anxiety, dizziness, stomach pain, urinary tract infections, muscle weakness, tiredness, and trouble sleeping.

Weight should be checked while the person is using EXELON PATCH. Weight loss/loss of appetite may occur. People below 50 kg (110 lbs) may experience more side effects and may have to stop using EXELON PATCH due to these side effects.

People at risk for stomach ulcers or who take certain medicines should tell their doctor before starting EXELON PATCH, because serious stomach problems, such as bleeding, may occur.

EXELON PATCH may cause fainting or slow heart rate; people with certain heart conditions should tell their doctor before starting therapy. People with serious lung conditions and difficulty breathing, bladder problems, or seizures should consult their doctor before using EXELON PATCH. Extrapyramidal symptoms (e.g., uncontrollable facial or body movements, including tremor and restlessness) could occur or get worse. Parkinsonian symptoms, particularly tremor, have worsened in Parkinson's disease dementia patients treated with EXELON (rivastigmine tartrate) capsules. Before using EXELON PATCH, people should also tell their doctor about any medical conditions they have, including if they have had a loss of appetite or are losing weight, or if they have had a skin reaction to rivastigmine (the medicine in EXELON PATCH) in the past. People on EXELON PATCH who feel dizzy or drowsy should not drive or use machines.

Tell the doctor about all other prescription or nonprescription medicines the patient is taking.

EXELON PATCH should not be taken at the same time with other medicines that have a similar effect on the body and the brain (cholinomimetic agents) or with anticholinergic medicines. Inform the doctor if the patient needs surgery requiring anesthesia while using EXELON PATCH.

Please see EXELON PATCH Full Prescribing Information and EXELON PATCH Patient Product Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

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